RNA sequencing analyses of gene expressions in a canine macrophages cell line DH82 infected with canine distemper virus.
Identifieur interne : 000075 ( Main/Exploration ); précédent : 000074; suivant : 000076RNA sequencing analyses of gene expressions in a canine macrophages cell line DH82 infected with canine distemper virus.
Auteurs : Xuexing Zheng [République populaire de Chine] ; Yelei Zhu [République populaire de Chine] ; Zhongxin Zhao [République populaire de Chine] ; Lina Yan [République populaire de Chine] ; Tong Xu [République populaire de Chine] ; Xianwei Wang [République populaire de Chine] ; Hongbin He [République populaire de Chine] ; Xianzhu Xia [République populaire de Chine] ; Wenwen Zheng [République populaire de Chine] ; Xianghong Xue [République populaire de Chine]Source :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-7257 ] ; 2020.
Abstract
Virulent morbillivirus infections, including Meals Virus (MeV) and Canine Distemper Virus (CDV), caused severe immune suppression and leukopenia, while attenuated vaccine strains developed protective host immune responses. However, the detailed molecular foundations of host antiviral responses were poorly characterized. In order to better understand the interactions between attenuated vaccine and host antiviral responses, the global gene expression changes in CDV-11-infected DH82 cells, a macrophage-derived cell line from canine, were investigated by transcriptomic analysis, and portions of results were confirmed with quantitative RT-PCR. The results exhibited that 372 genes significantly up-regulated (p < .01) and 119 genes were significantly down-regulated (p < .01) in CDV-infected macrophages DH82 at 48 h p.i.. The enriched functions of the significantly up-regulated (p < .01) genes were closely associated with interferon stimulated genes (ISGs), chemokine genes and pro-inflammatory factor genes. Gene ontology and pathway analysis of differentially expressed genes (DEGs) revealed that the most significantly involved pathways in CDV-infected DH82 cells were NF-κB and TNF signaling pathway, cytokine-cytokine receptor interaction, and pathogen associated molecular patterns (PAMPs), such as Toll-like, RIG-I-like and NOD-like receptor signalings. Thus, the findings indicated that pattern recognition receptors (PRRs) possibly mediated host innate and protective antiviral immune responses in CDV-11 infected DH82 cells.
DOI: 10.1016/j.meegid.2020.104206
PubMed: 31982604
Affiliations:
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Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address: red99.smile@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Infectious Diseases of Special Animal, Institute of Special Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130122</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31982604</idno><idno type="pmid">31982604</idno><idno type="doi">10.1016/j.meegid.2020.104206</idno><idno type="wicri:Area/Main/Corpus">000237</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000237</idno><idno type="wicri:Area/Main/Curation">000237</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000237</idno><idno type="wicri:Area/Main/Exploration">000237</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">RNA sequencing analyses of gene expressions in a canine macrophages cell line DH82 infected with canine distemper virus.</title><author><name sortKey="Zheng, Xuexing" sort="Zheng, Xuexing" uniqKey="Zheng X" first="Xuexing" last="Zheng">Xuexing Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. Electronic address: zhengxx2513@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, School of Public Health, Shandong University, Jinan 250012</wicri:regionArea><wicri:noRegion>Jinan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Yelei" sort="Zhu, Yelei" uniqKey="Zhu Y" first="Yelei" last="Zhu">Yelei Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhao, Zhongxin" sort="Zhao, Zhongxin" uniqKey="Zhao Z" first="Zhongxin" last="Zhao">Zhongxin Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, School of Public Health, Shandong University, Jinan 250012</wicri:regionArea><wicri:noRegion>Jinan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Lina" sort="Yan, Lina" uniqKey="Yan L" first="Lina" last="Yan">Lina Yan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, School of Public Health, Shandong University, Jinan 250012</wicri:regionArea><wicri:noRegion>Jinan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Tong" sort="Xu, Tong" uniqKey="Xu T" first="Tong" last="Xu">Tong Xu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, School of Public Health, Shandong University, Jinan 250012</wicri:regionArea><wicri:noRegion>Jinan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Xianwei" sort="Wang, Xianwei" uniqKey="Wang X" first="Xianwei" last="Wang">Xianwei Wang</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Shandong University, Qingdao 266237, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Shandong University, Qingdao 266237</wicri:regionArea><wicri:noRegion>Qingdao 266237</wicri:noRegion></affiliation></author><author><name sortKey="He, Hongbin" sort="He, Hongbin" uniqKey="He H" first="Hongbin" last="He">Hongbin He</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Shandong Normal University, Jinan 250014, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Shandong Normal University, Jinan 250014</wicri:regionArea><wicri:noRegion>Jinan 250014</wicri:noRegion></affiliation></author><author><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130122, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130122</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Zheng, Wenwen" sort="Zheng, Wenwen" uniqKey="Zheng W" first="Wenwen" last="Zheng">Wenwen Zheng</name><affiliation wicri:level="1"><nlm:affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, School of Public Health, Shandong University, Jinan 250012</wicri:regionArea><wicri:noRegion>Jinan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Xue, Xianghong" sort="Xue, Xianghong" uniqKey="Xue X" first="Xianghong" last="Xue">Xianghong Xue</name><affiliation wicri:level="1"><nlm:affiliation>Division of Infectious Diseases of Special Animal, Institute of Special Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address: red99.smile@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Division of Infectious Diseases of Special Animal, Institute of Special Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130122</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author></analytic><series><title level="j">Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases</title><idno type="eISSN">1567-7257</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Virulent morbillivirus infections, including Meals Virus (MeV) and Canine Distemper Virus (CDV), caused severe immune suppression and leukopenia, while attenuated vaccine strains developed protective host immune responses. However, the detailed molecular foundations of host antiviral responses were poorly characterized. In order to better understand the interactions between attenuated vaccine and host antiviral responses, the global gene expression changes in CDV-11-infected DH82 cells, a macrophage-derived cell line from canine, were investigated by transcriptomic analysis, and portions of results were confirmed with quantitative RT-PCR. The results exhibited that 372 genes significantly up-regulated (p < .01) and 119 genes were significantly down-regulated (p < .01) in CDV-infected macrophages DH82 at 48 h p.i.. The enriched functions of the significantly up-regulated (p < .01) genes were closely associated with interferon stimulated genes (ISGs), chemokine genes and pro-inflammatory factor genes. Gene ontology and pathway analysis of differentially expressed genes (DEGs) revealed that the most significantly involved pathways in CDV-infected DH82 cells were NF-κB and TNF signaling pathway, cytokine-cytokine receptor interaction, and pathogen associated molecular patterns (PAMPs), such as Toll-like, RIG-I-like and NOD-like receptor signalings. Thus, the findings indicated that pattern recognition receptors (PRRs) possibly mediated host innate and protective antiviral immune responses in CDV-11 infected DH82 cells.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31982604</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1567-7257</ISSN><JournalIssue CitedMedium="Internet"><Volume>80</Volume><PubDate><Year>2020</Year><Month>06</Month></PubDate></JournalIssue><Title>Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases</Title><ISOAbbreviation>Infect Genet Evol</ISOAbbreviation></Journal><ArticleTitle>RNA sequencing analyses of gene expressions in a canine macrophages cell line DH82 infected with canine distemper virus.</ArticleTitle><Pagination><MedlinePgn>104206</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1567-1348(20)30038-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.meegid.2020.104206</ELocationID><Abstract><AbstractText>Virulent morbillivirus infections, including Meals Virus (MeV) and Canine Distemper Virus (CDV), caused severe immune suppression and leukopenia, while attenuated vaccine strains developed protective host immune responses. However, the detailed molecular foundations of host antiviral responses were poorly characterized. In order to better understand the interactions between attenuated vaccine and host antiviral responses, the global gene expression changes in CDV-11-infected DH82 cells, a macrophage-derived cell line from canine, were investigated by transcriptomic analysis, and portions of results were confirmed with quantitative RT-PCR. The results exhibited that 372 genes significantly up-regulated (p < .01) and 119 genes were significantly down-regulated (p < .01) in CDV-infected macrophages DH82 at 48 h p.i.. The enriched functions of the significantly up-regulated (p < .01) genes were closely associated with interferon stimulated genes (ISGs), chemokine genes and pro-inflammatory factor genes. Gene ontology and pathway analysis of differentially expressed genes (DEGs) revealed that the most significantly involved pathways in CDV-infected DH82 cells were NF-κB and TNF signaling pathway, cytokine-cytokine receptor interaction, and pathogen associated molecular patterns (PAMPs), such as Toll-like, RIG-I-like and NOD-like receptor signalings. Thus, the findings indicated that pattern recognition receptors (PRRs) possibly mediated host innate and protective antiviral immune responses in CDV-11 infected DH82 cells.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Xuexing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China. Electronic address: zhengxx2513@163.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yelei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Zhongxin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Lina</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Tong</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xianwei</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Life Sciences, Shandong University, Qingdao 266237, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Hongbin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>College of Life Sciences, Shandong Normal University, Jinan 250014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Xianzhu</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130122, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Wenwen</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Virology, School of Public Health, Shandong University, Jinan 250012, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xue</LastName><ForeName>Xianghong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Division of Infectious Diseases of Special Animal, Institute of Special Animal and Plant Sciences, The Chinese Academy of Agricultural Sciences, Changchun 130122, China. Electronic address: red99.smile@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Infect Genet Evol</MedlineTA><NlmUniqueID>101084138</NlmUniqueID><ISSNLinking>1567-1348</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Antiviral responses</Keyword><Keyword MajorTopicYN="Y">Canine distemper virus</Keyword><Keyword MajorTopicYN="Y">Differentially expression genes</Keyword><Keyword MajorTopicYN="Y">Macrophages</Keyword><Keyword MajorTopicYN="Y">Transcriptomic</Keyword></KeywordList><CoiStatement>Declaration of Competing Interest No conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>01</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31982604</ArticleId><ArticleId IdType="pii">S1567-1348(20)30038-1</ArticleId><ArticleId IdType="doi">10.1016/j.meegid.2020.104206</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Dongbei</li><li>Jilin</li><li>Zhejiang</li></region><settlement><li>Changchun</li><li>Hangzhou</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zheng, Xuexing" sort="Zheng, Xuexing" uniqKey="Zheng X" first="Xuexing" last="Zheng">Xuexing Zheng</name></noRegion><name sortKey="He, Hongbin" sort="He, Hongbin" uniqKey="He H" first="Hongbin" last="He">Hongbin He</name><name sortKey="Wang, Xianwei" sort="Wang, Xianwei" uniqKey="Wang X" first="Xianwei" last="Wang">Xianwei Wang</name><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name><name sortKey="Xu, Tong" sort="Xu, Tong" uniqKey="Xu T" first="Tong" last="Xu">Tong Xu</name><name sortKey="Xue, Xianghong" sort="Xue, Xianghong" uniqKey="Xue X" first="Xianghong" last="Xue">Xianghong Xue</name><name sortKey="Yan, Lina" sort="Yan, Lina" uniqKey="Yan L" first="Lina" last="Yan">Lina Yan</name><name sortKey="Zhao, Zhongxin" sort="Zhao, Zhongxin" uniqKey="Zhao Z" first="Zhongxin" last="Zhao">Zhongxin Zhao</name><name sortKey="Zheng, Wenwen" sort="Zheng, Wenwen" uniqKey="Zheng W" first="Wenwen" last="Zheng">Wenwen Zheng</name><name sortKey="Zhu, Yelei" sort="Zhu, Yelei" uniqKey="Zhu Y" first="Yelei" last="Zhu">Yelei Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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